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Can we target    GSK3β        to prevent     Alzheimer       development?
Can we target&nbsp; &nbsp; GSK3<span>β</span>&nbsp; &nbsp; &nbsp; &nbsp; to prevent&nbsp; &nbsp; &nbsp;Alzheimer&nbsp; &nbsp; &nbsp; &nbsp;development?
<phosphorylates>
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<hyperphosphorylation
leads to>
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<inhibits>
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GSK3β phosphorylates tau at both primed sites (pThr-231) 
and unprimedsites (pSer-396/404)"
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UniProtKB : P49841
<div>UniProtKB :&nbsp;P49841</div>
Hyperphosphorylation of tau leads to the accumulation of neurofibrillary tangles
<span>Hyperphosphorylation of tau leads to the accumulation of neurofibrillary tangles</span>
SCTID : 85775002
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Alzheimer Disease pathology is characterized by Aβ plaques and tau-containing NFTs
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VPA concentration-dependently inhibits both GSK-3alpha and -3beta
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Drugbank : DB00313
<div><span>Drugbank : DB00313</span></div>
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UniProtKB : P10636
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ICD-10 : G30
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UniProtKB : P49841
<div>UniProtKB :&nbsp;P49841</div>
GSK3β
GSK3β
TAU
TAU
Neurofibrillary tangle
Neurofibrillary tangle
Alzheimer Disease
Alzheimer Disease
Valproic Acid
Valproic Acid
GSK3β
GSK3β

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