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Can we target    GSK3β        to prevent     Alzheimer       development?
Can we target&nbsp; &nbsp; GSK3<span>β</span>&nbsp; &nbsp; &nbsp; &nbsp; to prevent&nbsp; &nbsp; &nbsp;Alzheimer&nbsp; &nbsp; &nbsp; &nbsp;development?
<phosphorylates>
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<hyperphosphorylation
leads to>
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<is characterized by>
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<inhibits>
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GSK3β phosphorylates at both primed sites (pThr-231) 
and unprimedsites (pSer-396/404)"
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UniProtKB : P49841
<div>UniProtKB :&nbsp;P49841</div>
Hyperphosphorylation of tau leads to the accumulation of neurofibrillary tangles
<span>Hyperphosphorylation of tau leads to the accumulation of neurofibrillary tangles</span>
SCTID : 85775002
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Alzheimer Disease pathology is characterized by Aβ plaques and tau-containing NFTs
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VPA concentration-dependently inhibits both GSK-3alpha and -3beta
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Drugbank : DB00313
<div><span>Drugbank : DB00313</span></div>
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UniProtKB : P10636
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ICD-10 : G30.1
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UniProtKB : P49841
<div>UniProtKB :&nbsp;P49841</div>
GSK3β
GSK3β
TAU
TAU
Neurofibrillary tangle
Neurofibrillary tangle
Alzheimer Disease
Alzheimer Disease
Valproic Acid
Valproic Acid
GSK3β
GSK3β

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The platform takes all biomedical papers, trials, and projects and interlinks research findings in a semantic graph. Then, it mimics human reasoning to return discovered pathways and support your research

Send us your research question We'll try to extract biologically meaningful reasoning chains from all papers to answer the question and send them to you for your review



We are running pilot tests in the neurodegenerative disorders area right now; adding new questions to the pipeline can actually help in developing R&D strategy by producing a broader view